Purpose In soil-based nursery media, topsoil, poultry droppings and sawdust conventionally provide anchorage, nutrientsand aeration, respectively. Considering poultry droppings’ scarcity and sawdust’ s inertness nutrient-wise, more readily availableorganic wastes should be explored as substitutes. Here, we evaluated the effect of such substitution on media fertility, aimed at seeking alternatives to the conventional practice. Methods In a topsoil-manure-aerator volume ratio of 3: 2: 1, poultry droppings was substituted with pig slurry (slurry) orcattle dung (dung) as manure and sawdust with rice-husk dust (huskdust) as aerator, giving seven soil-based media includingreference medium (topsoil+droppings+sawdust) and the control (topsoil+topsoil+topsoil). They were watered regularly andanalysed for fertility parameters 4 months later. Results Reference had the highest pH (8. 60) and topsoil + dung + huskdust/control the lowest (6. 83). Substituting sawdustwith huskdust enhanced pH, organic matter and Mg2+in droppings/dung-amended media (topsoil+droppings+huskdust/topsoil+dung+huskdust) unlike slurry-amended ones where it too reduced total nitrogen (0. 19 vs 0. 11%). The substitution alsoenhanced available phosphorus in topsoil+droppings+huskdust (117. 50 mg kg− 1) and topsoil+dung+huskdust (71. 50 mg kg− 1)but reduced K+in the latter where it too had moderating effects on Na+. Reference surpassed topsoil+slurry+huskdustfor Ca2+, but was surpassed by topsoil+droppings+huskdust for Mg2+. Reference/topsoil+droppings+huskdust andtopsoil+slurry+huskdust/control showed highest and lowest CEC, respectively. Excluding pH, topsoil+dung+huskdust andtopsoil+slurry+sawdust were, notably, consistently similar. Overall, droppings-amended > dung-amended > slurry-amendedmedia and, for available phosphorus only, sawdust-aerated < huskdust-aerated media. Conclusion Based on fertility status 4 months after blending, topsoil+droppings+huskdust could serve as alternative tothe conventional nursery medium, or topsoil+dung+huskdust where near-neutral pH is preferred to increased phosphorus/cations release.